In Vitro Characterization of Conditions for Amyloid-β Peptide Oligomerization and Fibrillogenesis
نویسندگان
چکیده
منابع مشابه
In vitro characterization of conditions for amyloid-beta peptide oligomerization and fibrillogenesis.
Extensive research causally links amyloid-beta peptide (A beta) to Alzheimer's disease, although the pathologically relevant A beta conformation remains unclear. A beta spontaneously aggregates into the fibrils that deposit in senile plaques. However, recent in vivo and in vitro reports describe a potent biological activity for oligomeric assemblies of A beta. To consistently prepare in vitro o...
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ژورنال
عنوان ژورنال: Journal of Biological Chemistry
سال: 2003
ISSN: 0021-9258
DOI: 10.1074/jbc.m210207200